Among da neurons, the class I (C-I) and class IV (C-IV) neurons represent examples of two extremes of dendritic complexity, where C-I neurons exhibit selective innervations of dendritic territories and occupy relatively small receptive fields, whereas C-IV neurons exhibit an elaborate space-filling network of dendrites that completely and non-redundantly tile the larval body wall. The da neurons consist of 4 distinct morphological and functional classes (C-I-IV) of sensory neurons that have varying degrees of dendritic complexity. ĭrosophila dendritic arborization (da) sensory neurons have emerged as a powerful system to investigate class-specific dendritogenesis due to their distinct and well-characterized dendritic morphology (reviewed in – ). Moreover, in humans, defects in dendritic development are among the strongest neuroanatomical correlates to neurological and neuro-developmental disorders including Down, Fragile X, and Rett syndromes as well as Autism. Dendritic branching pattern represents a hallmark of each neuronal type, and plays a functional role in signal-processing, neuronal function and circuit assembly. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Ī complex nervous system consists of a vast number of neuronal classes, each displaying distinctive dendritic architecture. and Kate Miller Jeffress Memorial Trust for support of this research. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: The authors acknowledge the National Institutes of Health (MH086928-02) ( ) and the Thomas F. Received: Accepted: JPublished: August 15, 2013Ĭopyright: © 2013 Iyer et al.
McCabe, Columbia University, United States of America (2013) Functional Genomic Analyses of Two Morphologically Distinct Classes of Drosophila Sensory Neurons: Post-Mitotic Roles of Transcription Factors in Dendritic Patterning. Citation: Iyer EPR, Iyer SC, Sullivan L, Wang D, Meduri R, Graybeal LL, et al.
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